Identification of Medical Raw Materials by Raman Spectrometer
Identification of Medical Raw Materials by Raman Spectrometer
author: Joy
2022-01-06
Traditional inspection methods to detect raw and auxiliary materials of medicine to identify the impact of packaging on test results will lead to a large increase in quality inspection workload, and cost a lot of manpower and financial resources, and greatly increase the risk of human error. The use of handheld Raman spectrometer for material receiving identification and improve work efficiency has become a necessary means, but also as far as possible to reduce the cost of testing, handheld Raman spectroscopy as a new, efficient, rapid, nondestructive testing method has been accepted by more and more users.At the same time, some pharmaceutical companies want their devices to be as efficient as possible in penetrating various packaging materials.

Fig 1Pharmaceutic Adjuvant
Principle: Raman Scattering Spectroscopy
Light on matter scatters both elastic and inelastic. The scattered light of elastic scattering has the same wavelength as the excited light, while the scattered light of inelastic scattering has the longer and shorter components than the excited light, collectively known as the Raman effect.
Test Substance: Sucrose (AR grade)
Packing Material: transparent white PE bottle, transparent PE bottle and transparent PE ziplocking bag.
Light on matter scatters both elastic and inelastic. The scattered light of elastic scattering has the same wavelength as the excited light, while the scattered light of inelastic scattering has the longer and shorter components than the excited light, collectively known as the Raman effect.
Test Substance: Sucrose (AR grade)
Packing Material: transparent white PE bottle, transparent PE bottle and transparent PE ziplocking bag.

Fig 2Transparent White PE Bottle

Fig 3Transparent PE Ziplock

Fig 4Transparent PE Bottle
Test Result:

Fig 5Raman Spectra Measured By Different Packaging
1.The instrument can detect the contents through transparent or even non-transparent packaging;
2. The packaging material will reduce the Raman signal, the thicker the packaging, the weaker the Raman signal;
3. Identification effect: transparent thin packaging > transparent thick packaging > non-transparent thin packaging;
2. The packaging material will reduce the Raman signal, the thicker the packaging, the weaker the Raman signal;
3. Identification effect: transparent thin packaging > transparent thick packaging > non-transparent thin packaging;
4. Pharmaceutical enterprises mostly use double packaging of raw materials (outer paper bucket or plastic bucket + inner PE bag), so the instrument can not be opened inside.In the case of layer packaging, the contents are tested to meet customer identification needs.
Conclusion:
Raman spectroscopy is a legal analysis method recognized by The Chinese Pharmacopoeia, the United States pharmacopoeia and the European Pharmacopoeia, which is suitable for 100% identification of raw materials, intermediates and packaging materials.Raman spectroscopy is a modern analysis method based on Raman scattering phenomenon. It is widely used in medicine because of its advantages of high sensitivity and simple operation, which does ot require special pretreatment of samples during detection. The handheld Raman spectrometer instrument is intuitive and simple to operate. It uses a matteroffact, nondestructive sampling design to quickly test various compounds in a transparent, sealed package, effectively minimizing contamination and exposure risks.
Related Products:
ATR6500
ATR6600
Related Products:
ATR6500
ATR6600
Related News
Microscopic Raman Spectroscopy for Graphene Sample Testing
2023-03-15 587Get the principles and applications of ATR
2023-09-18 32Optimising confocal Raman microscopy for spectral mapping of cement-based materials
2023-09-04 53Application of Confocal Micro Raman Spectroscopy in Interface Research
2023-09-04 37Existing Standards,Guides and Practices for Raman Spectroscopy
2023-08-31 48ATR8800 Raman Imaging Technology
2023-08-23 62Raman Spectroscopy and its Most Common Applications
2023-01-17 513Raman : Applications
2023-01-17 539Application of Raman Spectroscopy in Characterization of Graphene Structure
2023-01-17 418Food Analysis and Raman Spectroscopy
2023-01-17 510Raman or FTIR Spectroscopy
2023-01-12 515What is Raman Spectroscopy?
2023-01-12 409Raman spectroscopic detection and analysis of Scutellaria baicalensis herbal tablets
2022-12-23 409What is X-ray Fluorescence (XRF)
2022-12-22 483What is the Raman microscope?
2022-12-22 456What is the SERS?
2022-12-22 425(Suzhou Institute of Biomedical Engineering Technology, Chinese Academy of Sciences)Escherichia coli sample and Staphylococcus aureus Raman spectrum detection report on silver substrate
2022-12-15 354What Is Raman Spectroscopy Used For?
2022-12-09 380Test Report of Insulating Oil and Insulating Paper of Electrical Engineering College of Chongqing University
2022-12-05 314ATR8300-1064 high sensitive near-infrared microRaman spectrometer was used to rapidly identify textile components
2022-12-01 458